中國醫藥大學圖書館藏資料
資料類型BOOK
書刊名Oral bioavailability assessment :basics and strategies for drug discovery and development /Ayman F. El-Kattan.
出版地/出版者/出版年Hoboken, NJ :John Wiley & Sons Inc.,2017.
稽核項viii, 436 p. :ill. ;25 cm.
叢書名Wiley series on pharmaceutical science and biotechnology: practices, applications, and methods
國際標準書號/價格9781118916940$q(Adobe PDF)
國際標準書號/價格9781118916933$q(ePub)
國際標準書號/價格9781118916698
標題Biological Availability.
標題Drug Evaluation, Preclinical.
標題Toxicokinetics.
標題Administration, Oral.
主要作者El-Kattan, Ayman F.
內容註Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.
附註Includes bibliographical references and index.
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  QV38  EL51o  2017    

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